Timo Comod 0.5% Eye Drops

✔️ Side Effects of Timo-Comod 0.5% eye Drops

Ocular:

Mild irritation (e.g., conjunctivitis, keratitis, blepharitis)

Visual disturbances, including refractive changes (especially after stopping miotics)

Cardiovascular:

Bradycardia, arrhythmias, hypotension, heart block, syncope, cardiac arrest

Respiratory:

Dyspnea, bronchospasm, respiratory failure (especially in asthmatic patients)

Systemic:

Headache, nausea, dizziness, fatigue, depression

✔️ Dosage & Administration of Timo Comod 0.5% Eye Drops

Initial dose: One drop of 0.25% solution, instilled into the affected eye twice daily.

If intraocular pressure is not adequately controlled, increase to a 0.50% solution, one drop twice daily.

Once pressure stabilizes, dosage may be reduced to once daily based on clinical evaluation after about 4 weeks.

Pediatric use: Not recommended in premature infants or newborns due to a lack of clinical studies.

✔️ Drug Interactions

Systemic beta-blockers may amplify the hypotensive and bradycardic effects.

Caution when used with adrenaline-containing eye drops, as pupil dilation (mydriasis) may occur.

Clinical supervision is advised with concomitant therapies that may depress cardiac or respiratory function.

✔️ Contraindications

Known hypersensitivity to Timolol or formulation components

Patients with:

• Bronchial asthma or severe COPD
• Uncontrolled heart failure or cardiogenic shock
• Severe bradycardia (<45–50 bpm)
• High-degree AV block

Timolol may be absorbed systemically and can exert systemic beta-blocker effects. Caution is advised in elderly and cardiac-compromised patients.

✔️ Use with Contact Lenses

Use is generally well tolerated, but wearing contact lenses during treatment is discouraged due to:

Reduced tear secretion from beta-blockers

Possible drug absorption onto lenses

✔️ Pregnancy & Lactation

Safety in human pregnancy has not been adequately established.

Use only if the potential benefit justifies the potential risk to the fetus or nursing infant.

✔️ Precautions & Warnings

Monitor closely in patients with:

• Cardiac conditions, cerebrovascular disease, diabetes mellitus, myasthenia gravis, or thyrotoxicosis
• Renal or hepatic impairment
• Avoid abrupt withdrawal in coronary artery disease—it may worsen angina or trigger myocardial infarction.
• May mask symptoms of hypoglycemia or hyperthyroidism.
• Avoid monotherapy in angle-closure glaucoma.
• Use with caution in pregnancy and lactation.

✔️ Storage Instructions

• Store at 15°C to 25°C, protected from light and moisture
• Use within 30 days after first opening
• Close the bottle tightly after each use
• Keep out of reach of children